Cellular mechanisms underlying steroid-resistant asthma
نویسندگان
چکیده
منابع مشابه
Steroid-resistant asthma.
The current study examined whether alterations in glucocorticoid receptor (GR) binding contribute to poor response to glucocorticoid therapy in asthma. 29 asthma patients with forced expiratory volume in 1 s (FEV1) < 70% predicted were studied. Patients were classified as steroid sensitive (SS) if their morning FEVI increased > 30% after a I-wk course of oral prednisone 20 mg twice daily and st...
متن کاملSteroid resistant asthma.
Inspite of very safe and effective treatment, Bronchial asthmatics do not respond well in 5-10% of cases which are labelled as Refractory Asthma. Besides compliance, presence of psychogenic and trigger factors and comorbid illness, steroid insensitiveness or resistance may play a significant role in the poorly controlled/responding asthmatics. Type I Steroid resistance is due to lack of binding...
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Asthma is a phenotypically heterogeneous chronic disease of the airways, characterized by either predominant eosinophilic or neutrophilic, or even mixed eosinophilic/neutrophilic inflammatory patterns. Eosinophilic inflammation can be associated with the whole spectrum of asthma severity, ranging from mild-to-moderate to severe uncontrolled disease, whereas neutrophilic inflammation occurs most...
متن کاملShort paper Pseudo-steroid resistant asthma
Background—Steroid resistant asthma (SRA) represents a small subgroup of those patients who have asthma and who are diYcult to manage. Two patients with apparent SRA are described, and 12 additional cases who were admitted to the same hospital are reviewed. Methods—The subjects were selected from a tertiary hospital setting by review of all asthma patients admitted over a two year period. Subje...
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The muscular dystrophies are a group of heterogeneous genetic diseases characterized by progressive degeneration and weakness of skeletal muscle. Since the discovery of the first muscular dystrophy gene encoding dystrophin, a large number of genes have been identified that are involved in various muscle-wasting and neuromuscular disorders. Human genetic studies complemented by animal model syst...
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ژورنال
عنوان ژورنال: European Respiratory Review
سال: 2019
ISSN: 0905-9180,1600-0617
DOI: 10.1183/16000617.0096-2019